Preclinical
Does Catestatin Peptide Reduce Tau, Amyloid, and Neuroinflammation in Preclinical Alzheimer's Disease Models in 2026?
In preclinical models studied through 2026, catestatin (CST) — a 21-amino-acid peptide derived from chromogranin A — reduces tau hyperphosphorylation and aggregation, lowers amyloid plaque burden, suppresses glial neuroinflammation, and restores both cognitive and motor function. All evidence is from rodent models; no human clinical trials have been initiated as of 2026.
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